Beilstein J. Org. Chem.2014,10, 141–149, doi:10.3762/bjoc.10.11
, P.O. Box 83523, Qena, Egypt 10.3762/bjoc.10.11 Abstract Novel routes for the preparation of 2-amino-4H-pyran-3-carbonitrile 9, amino-arylbenzoicacid ester derivatives 13a,b, 2-aminotetrahydro-4H-chromene-3-carbonitrile 18, 3-amino-4-cyanotetrahydronaphthalene-2-carboxylic acid ester 26 and 4-amino
-oxo-5-phenyl-3H-isoindole-4-carboxylate (40).
Keywords: aminopyranes; arylbenzoicacid; DABCO; L-proline; multicomponent; tetrahydronaphthalene; three-component reaction; Introduction
The reaction of arylidenemalononitriles with active methyl and methylene compounds was extensively utilized for the
PDF
Graphical Abstract
Scheme 1:
Reaction of active methylenenitriles with α,β-unsaturated ketones 1.